Urokinase Plasminogen Activator Receptor (uPAR) Targeted Therapy with Switchable Chimeric Antigen Receptor T-Cell (sCAR T-Cell) Potential as Pancreatic Cancer Immunotherapy Agent

Authors

  • Tungki Pratama Umar Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia
  • Muhammad Syahrul Ramadhan Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia
  • Nindya Mahfuza Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia

DOI:

https://doi.org/10.31344/ijhhs.v5i2.255

Keywords:

Pancreatic cancer, Immunotherapy, sCAR T-cells, uPAR

Abstract

Pancreatic cancer is the cancer with highest mortality-incidence rate compared with other types of cancer. Most cases can only be treated palliatively. Targeted therapy comes as an alternative to its treatment especially with Switchable CAR T-cells (sCAR T-cells). In pancreatic cancer, urokinase plasminogen activator receptor (uPAR) is a specific target that is excessively expressed in tumor cell microenvironment. Targeted therapy using sCAR T-cells has been proved safe and effective in other types of malignancy such as B cell lymphoma, so it has potency as immunotherapy agent in pancreatic cancer patient.

International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 171-176

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Published

2020-10-04

How to Cite

Umar, T. P., Ramadhan, M. S., & Mahfuza, N. (2020). Urokinase Plasminogen Activator Receptor (uPAR) Targeted Therapy with Switchable Chimeric Antigen Receptor T-Cell (sCAR T-Cell) Potential as Pancreatic Cancer Immunotherapy Agent. International Journal of Human and Health Sciences (IJHHS), 5(2), 171–176. https://doi.org/10.31344/ijhhs.v5i2.255

Issue

Vol. 5 No. 2 (2021)

Section

Review Articles

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