The Prevalence and Prognostic Value of BRAFV600E Mutation in Papillary Thyroid Cancer

Authors

  • Alaa Al Maaitah Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Moaath Alsmady Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Shatha Dmour Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Dana Alsmady Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Ahmad Al Alwan Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Mira Younis Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Mohammad Al Shhab Department of Pharmacology, School of Medicine,The University of Jordan. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Malek Zihlif Department of Pharmacology, School of Medicine,The University of Jordan. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Heyam Awad Department of Pathology, School of Medicine, The University of Jordan. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Handan Ankaralı Department of Biostatistics, School of Medicine, Istanbul Medeniyet University. D100 Street, North Campus, Üsküdar, 34700, Istanbul, Turkey
  • Nader Albsoul Department of General Surgery, School of Medicine, The University of Jordan, Jordan University Hospital. Queen Rania Street, Aljubeiha, Amman 11942 Jordan
  • Orhan Alimoglu Department of General Surgery, School of Medicine, Istanbul Medeniyet University. Dr. Erkin Street, Goztepe, Kadikoy, 34730, Istanbul, Turkey and Department of General Surgery, School of Medicine, University of Jordan, (Visiting Professor). Queen Rania Street, Aljubeiha, Amman 11942 Jordan

DOI:

https://doi.org/10.31344/ijhhs.v3i4.106

Keywords:

Papillary thyroid carcinoma, BRAF kinases, prognosis

Abstract

Objective: B-type Raf kinase (BRAF)V600E mutation in papillary thyroid cancer (PTC) has variable prevalence worldwide and it is hypothesized to worsen tumor prognosis. This study was conducted to investigate the prevalence of BRAFV600E mutation among PTC patients and to find out its prognostic impact measured by its association with various clinicopathologic features, recurrence, and mortality.

Methods: This is a retrospective study that included 123 PTC patients who underwent thyroidectomy at Jordan University Hospital between January 2010 and December 2015. They were followed up over a mean of 18 months (range: 4-72). BRAFV600E mutation was analyzed by direct sequencing. A p value less than 0.05 was defined as statistically significant.

Results: Twenty three out of 123 (18.7%) PTC patients were BRAFV600E mutation positive. BRAFV600E- mutant patients were more likely to have larger tumor size (1.8 vs 2.5 cm, p=0.040), to present with lymph node metastasis (LNM) (41.2% vs 82.4%, p=0.002), and to develop recurrence (1 vs 3, p=0.0003). Moreover, tumor recurrence which was recorded in 4 patients was significantly associated with LNM (p=0.038). Cancer-specific mortality rate was null.

Conclusion: BRAFV600E mutation rate in PTC was low relative to world-wide prevalence. BRAFV600E mutation has prognostic value for PTC management. However, its cost-effectiveness should be revised. Further larger prospective studies in the region are recommended.

International Journal of Human and Health Sciences Vol. 03 No. 04 October’19 Page : 223-230

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Published

2019-09-01

How to Cite

Maaitah, A. A., Alsmady, M., Dmour, S., Alsmady, D., Alwan, A. A., Younis, M., … Alimoglu, O. (2019). The Prevalence and Prognostic Value of BRAFV600E Mutation in Papillary Thyroid Cancer. International Journal of Human and Health Sciences (IJHHS), 3(4), 223–230. https://doi.org/10.31344/ijhhs.v3i4.106

Issue

Vol. 3 No. 4 (2019)

Section

Original Articles

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