Detection of Serum Vascular Endothelial Growth Factors (VEGF) And Soluble Vascular Endothelial Growth Factors (sVEGF / sflt-1) of Pregnancy Induced Hypertension Mothers (PIH) With pathological changes of Placenta In a Tertiary Care Hospital of West Bengal.

Authors

  • Sulekha Ghosh Professor of Pathology, B.S. Medical College, Bankura, West Bengal
  • Kabayashree Jana PGT, Pathology, B.S. Medical College, Bankura
  • Pratima Mandal PGT , Pathology, B.S. Medical College, Bankura
  • Trithankar Chakrabarty PGT, Pathology, B.S. Medical College, Bankura
  • Debasis Bhattacharya Ex, Principal, NRS Medical College, Kolkata
  • Tapan Kumar Ghosh Director, RBTC, B.S. Medical College, Bankura

DOI:

https://doi.org/10.31344/ijhhs.v2i1.21

Keywords:

Pregnancy induced hypertension, vascular endothelial growth factors, soluble vascular endothelial growth factors

Abstract

Introduction:Pregnancy Induced Hypertension (PIH) results from imbalance between pro-angiogenic factors (VEGF & PIGF) and antiangiogenic factors (sVEGFR-1/sflt- 1)

Subjects and methodology: A mixed random study comprising of random cases of different gestational ages 28-36 wks of PIH mothers along with control cases till completion of pregnancy after delivery. Age of enrolled mothers and their gestational age, blood pressure, serum free VEGF and sVEGFR-1(sflt1) were compared in both groups (control n=36, PIH n=36). Blood pressure of both control and PIH mothers just before and after delivery showed significant correlation (p<0.0001). Serum levels of free VEGF were lower among PIH mothers at 28-36 wks (p <0.0001) and just before delivery (JBD) (p <0.0001) than normal control antenatal mothers and more or less similar in both groups at just after delivery (p <0.390). Serum sflt1 level (6459.81 ±1811.07 pg/ml) of PIH mothers showed higher value than control mothers (1062.19 ± 165.98 pg/ml) at the time of presentation and also just before delivery(JBD) & after delivery(JAD) and was highly significant ( p < 0.0001). Serum free VEGF level of PIH mothers was negatively correlated with systolic r= - 0.247, p = 0.147) and diastolic (r =-0.220, p =0.197) blood pressure. The increased serum sflt1 level of PIH mothers was positively correlated with systolic (r = 0.299, p = 0.07) and diastolic (r = 0.309, p = 0.067) blood pressure. Semi quantitative expression of VEGF R1 and PCNA LI of placenta showed increased (3+) expression of VEGF R1 of 13 (43.33%) and > 50% PCNA LI expression of 12 (40%) cases than control.

Discussion &Conclusion:The elevated levels of systolic and diastolic blood pressure along with alteration of proangiogenic and angiogenic growth factors among PIH mothers than normotensive control may help to identify PIH mothers as early as possible and referring them to higher/tertiary centers for better management and prevention of its grave complications of PIH.

International Journal of Human and Health Sciences Vol. 02 No. 01 Jan’18. Page : 25-30

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Published

2018-02-01

How to Cite

Ghosh, S., Jana, K., Mandal, P., Chakrabarty, T., Bhattacharya, D., & Ghosh, T. K. (2018). Detection of Serum Vascular Endothelial Growth Factors (VEGF) And Soluble Vascular Endothelial Growth Factors (sVEGF / sflt-1) of Pregnancy Induced Hypertension Mothers (PIH) With pathological changes of Placenta In a Tertiary Care Hospital of West Bengal. International Journal of Human and Health Sciences (IJHHS), 2(1), 25–30. https://doi.org/10.31344/ijhhs.v2i1.21

Issue

Vol. 2 No. 1 (2018)

Section

Original Articles

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